The  Round of 16 games have been concluded and the final eight teams have emerged. The draws were announced on the 17th of May, 2008 in Cameroon.

Group A

Teams	GP	W	D	L	GF	GA	GD	Pts
Al-Ahly	3	2	1	0	4	2	+2	7
Al-Zamalek	3	1	1	1	2	2	0	4
Dynamos	3	1	0	2	3	4	-1	3
ASEC Mimosas	3	0	2	1	1	2	-1	2

2008-07-20 17:30 GMT	Al Ahly	2 - 1	Zamalek	Cairo Stadium, Cairo Referee: Coffi Codjia
	Flavio  28' Hassan  67'		Hamza  62'

2008-07-20 13:00 GMT	Dynamos	2 - 1	ASEC Mimosas	Rufaro Stadium, Harare Referee: Divine Evehe
	Sadomba  4'  73'		Wawa  30'

2008-08-02 15:30 GMT	ASEC Mimosas	0 - 0	Al Ahly	Stade Felix Houphouet-Boigny, Abidjan Referee: Badara Diatta

2008-08-03 18:00 GMT	Zamalek	1 - 0	Dynamos	Cairo Stadium, Cairo Referee: Mohamed Benouza
	El Safty  4'

2008-08-17 17:00 GMT	Al Ahly	2 - 1	Dynamos	Cairo Stadium, Cairo

2008-08-16 18:00 GMT	Zamalek	0 - 0	ASEC Mimosas	Cairo Stadium, Cairo

2008-08-30 12:30 GMT	Dynamos	v	Al Ahly	Rufaro Stadium, Harare

2008-08-31 15:30 GMT	ASEC Mimosas	v	Zamalek	Stade Felix Houphouet-Boigny, Abidjan

2008-09-14 20:00 GMT	Zamalek	v	Al Ahly	Cairo Stadium, Cairo

2008-09-13 15:30 GMT	ASEC Mimosas	v	Dynamos	Stade Felix Houphouet-Boigny, Abidjan

2008-09-21 19:00 GMT	Dynamos	v	Zamalek	Rufaro Stadium, Harare

2008-09-21 20:00 GMT	Al Ahly	v	ASEC Mimosas	Cairo Stadium, Cairo

Group B

Teams	GP	W	D	L	GF	GA	GD	Pts
Enyimba FC	3	2	0	1	6	3	+3	6
Al Hilal	3	1	2	0	4	3	+1	5
Cotonsport	3	1	1	1	2	3	-1	4
TP Mazembe	3	0	1	1	0	3	-3	1

2008-07-19 14:30 GMT	Cotonsport Garoua	1 - 0	TP Mazembe	Stade Omnisports Roumde-Adja, Garoua Referee: Koman Coulibaly
	Kamilou  90'

2008-07-18 17:00 GMT	Al Hilal	3 - 2	Enyimba	AlHilal Stadium, Omdurman Referee: Ahmed Auda
	Mustafa  41' Mohamed  47' Eviani  90'		Itodo  35' Worgu  88'

2008-08-03 15:00 GMT	Enyimba	2 - 0	Cotonsport	Enyimba International Stadium, Aba Referee: Eddy Maillet
	Otorogu  1H' Worgu  2H'

2008-08-02 13:00 GMT	TP Mazembe	0 - 0	Al Hilal	Stade Municipal, Lubumbashi Referee: Mathews Katjimune

2008-08-15 17:00 GMT	Al Hilal	1 - 1	Cotonsport	AlHilal Stadium, Omdurman

2008-08-17 14:30 GMT	Enyimba	2 - 0	TP Mazembe	Enyimba International Stadium, Aba

2008-08-30 15:00 GMT	Cotonsport Garoua	v	Al Hilal	Stade Omnisports Roumde-Adja, Garoua

2008-08-31 13:00 GMT	TP Mazembe	v	Enyimba	Stade Municipal, Lubumbashi

2008-09-14 12:30 GMT	TP Mazembe	v	Cotonsport	Stade Municipal, Lubumbashi

2008-09-14 15:00 GMT	Enyimba	v	Al Hilal	Enyimba International Stadium, Aba

2008-09-20 19:00 GMT	Cotonsport Garoua	v	Enyimba	Stade Omnisports Roumde-Adja, Garoua

2008-09-20 20:00 GMT	Al Hilal	v	TP Mazembe	AlHilal Stadium, Omdurman